An efficient method to assess gene-environment interactions

case-base study_1

Many diseases result from interactions between genes and environmental exposures. Professor Wen-Chung Lee and Dr. Tina (繼續閱讀…)

2014-09-26

Detecting a weak association by testing its multiple perturbations

P1030952

Many risk factors and interventions addressed in epidemiologic and biomedical studies have been shown to have minimal effects. To detect such weak associations, (繼續閱讀…)

2014-07-01

Alternative performance measures for prediction models

AUC

           Risk prediction models are important for patients and physicians alike. As a measure of prediction performance, (繼續閱讀…)

2014-04-15

A data-mining perturbation analysis to detect and correct the bias of unmeasured factors

perturbation

          The randomized controlled study is the gold-standard for research methodology in biomedicine, and the validity of a (nonrandomized) observational study is often questioned because of unknown/unmeasured factors (U). Professor Wen-Chung Lee (繼續閱讀…)

2014-03-19

The ‘Peril Ratio’: an alternative effect measure in epidemiology

peril ratio

          In epidemiology, the effect of an exposure can be measured either on a ratio scale, e.g., risk ratio, odds ratio or rate ratio, or on a difference scale, e.g., risk difference, odds difference or rate difference. An effect can (繼續閱讀…)

2014-02-27

Pathway analysis using information from allele-specific gene methylation in genome-wide association studies for bipolar disorder

Dr Kuo

           Pathway-based analytic strategy is a powerful tool with which to explore the joint effects of gene sets within specific biological pathways. The aim of this study (繼續閱讀…)

2014-02-27

Association between metabolome and low bone mineral density in Taiwanese women determined by 1H NMR Spectroscopy

Karen Chen

          Osteoporosis is related to alterations in specific circulating metabolites. This was the first study to assess the relationship between metabolome (繼續閱讀…)

2014-02-19

Comparison of predictive performance of various fatty acids for the risk of cardiovascular disease events and all-cause deaths in a community-based cohort

Chien

         The issue of whether saturated fats and trans fats are superior predictors of death from all causes and cardiovascular disease (CVD) than are n-3 polyunsaturated fatty acids, (繼續閱讀…)

2014-02-19

A regression-based method for estimating risks and relative risks in case-base studies

Lee

          The case-base study is a hybrid design (part case-control, part cohort). In terms of study costs and time, it is like the more economical case-control study; (繼續閱讀…)

2014-02-19

GSTP1 is a hub gene for gene-air pollution interactions on childhood asthma

李永凌老師

           By identifying the effects of air pollution on the general population, the effects of air pollution on childhood asthma (繼續閱讀…)

2014-02-19

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